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Ketamine acts by blocking receptors in the brain called NMDA receptors. The blockade of these receptors leads to increased mTOR pathway signaling, increased AMPA receptor activation, and increased development and efficacy of synapses in the brain, leading to an anti-depressant effect.
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Ketamine was placed on the list of controlled substances in the US in 1999. Ketamine is used for Inducing anesthesia, which may be lack of feeling before surgery or some procedures that do not require skeletal muscle relaxation. It may also be used for other conditions as prescribed by your doctor. Ketamine is anaesthetic and works in the brain to inhibit painful sensations.
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